Artificial Selection for Pathogenicity Mutations in Staphylococcus aureus Identifies Novel Factors Relevant to Chronic Infection

Author:

McLean Kathryn1,Holmes Elizabeth A.1,Penewit Kelsi1,Lee Duankun K.1,Hardy Samantha R.1,Ren Mingxin1,Krist Maxwell P.1,Huang Kevin1,Waalkes Adam1,Salipante Stephen J.1

Affiliation:

1. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA

Abstract

Adaptation of Staphylococcus aureus to host microenvironments during chronic infection involves spontaneous mutations, yet changes underlying adaptive phenotypes remain incompletely explored. Here, we employed artificial selection and whole-genome sequencing to better characterize spontaneous chromosomal mutations that alter two pathogenicity phenotypes relevant to chronic infection in S. aureus : intracellular invasiveness and intracellular cytotoxicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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