Activity of Aztreonam in Combination with Avibactam, Clavulanate, Relebactam, and Vaborbactam against Multidrug-Resistant Stenotrophomonas maltophilia-Reference-Cited by-同舟云学术

Activity of Aztreonam in Combination with Avibactam, Clavulanate, Relebactam, and Vaborbactam against Multidrug-Resistant Stenotrophomonas maltophilia

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Biagi M.¹,Lamm D.¹,Meyer K.¹,Vialichka A.¹,Jurkovic M.¹,Patel S.¹,Mendes R. E.²^ORCID,Bulman Z. P.¹^ORCID,Wenzler E.¹^ORCID

Affiliation:

1. College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

2. JMI Laboratories, North Liberty, Iowa, USA

Abstract

The intrinsic L1 metallo- and L2 serine-β-lactamases in Stenotrophomonas maltophilia make it naturally multidrug resistant and difficult to treat. There is a need to identify novel treatment strategies for this pathogen, especially against isolates resistant to first-line agents. Aztreonam in combination with avibactam has demonstrated potential, although data on other aztreonam–β-lactamase inhibitor (BLI) combinations are lacking. Additionally, molecular mechanisms for reduced susceptibility to these combinations have not been explored.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00297-20

Reference45 articles.

1. Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistantStenotrophomonas maltophiliaclinical isolates

2. Sequence analysis and enzyme kinetics of the L2 serine beta-lactamase from Stenotrophomonas maltophilia

3. Purification of β-lactamases by affinity chromatography on phenylboronic acid-agarose

4. Global Emergence of Trimethoprim/Sulfamethoxazole Resistance inStenotrophomonas maltophiliaMediated by Acquisition ofsulGenes

5. Emerging Importance of Multidrug‐ResistantAcinetobacterSpecies andStenotrophomonas maltophiliaas Pathogens in Seriously Ill Patients: Geographic Patterns, Epidemiological Features, and Trends in the SENTRY Antimicrobial Surveillance Program (1997–1999)

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