Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence IS Aba36 in the siderophore receptor pirA-Reference-Cited by-同舟云学术

Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence IS Aba36 in the siderophore receptor pirA

Published:2024-07-09 Issue:7 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang En¹^ORCID,Thompson Rebekah N.²,Moon Sun Hee¹,Keck Jacob M.³,Lowry Michael S.²,Melero Joe⁴,Jun Se-Ran⁵^ORCID,Rosenbaum Eric R.⁴^ORCID,Dare Ryan K.²^ORCID

Affiliation:

1. Department of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

2. Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

3. Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

4. Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

5. Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Abstract

ABSTRACT We report the emergence of cefiderocol resistance in a bla OXA-72 carbapenem-resistant Acinetobacter baumannii isolate from a sacral decubitus ulcer. Cefiderocol was initially used; however, a newly approved sulbactam-durlobactam therapy with source control and flap coverage was successful in treating the infection. Laboratory investigation revealed cefiderocol resistance mediated by IS Aba36 insertion into the siderophore receptor pirA .

Funder

HHS | NIH | National Institute of General Medical Sciences

University of Arkansas for Medical Sciences

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00290-24

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