SOS-Independent Induction of dinB Transcription by β-Lactam-Mediated Inhibition of Cell Wall Synthesis in Escherichia coli-Reference-Cited by-同舟云学术

SOS-Independent Induction of dinB Transcription by β-Lactam-Mediated Inhibition of Cell Wall Synthesis in Escherichia coli

Published:2005-02-15 Issue:4 Volume:187 Page:1515-1518
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Pérez-Capilla Tatiana¹,Baquero María-Rosario²,Gómez-Gómez José-María³,Ionel Alina¹,Martín Soledad¹,Blázquez Jesús¹

Affiliation:

1. Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, Universidad Autónoma de Madrid

2. Servicio de Microbiología, Hospital Ramón y Cajal

3. Laboratorio de Evolución Microbiana, Centro de Astrobiología (INTA-CSIC), Madrid, Spain

Abstract

ABSTRACT Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the β-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.187.4.1515-1518.2005

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