Human Immunodeficiency Virus Type 1 Replication and Regulation of APOBEC3G by Peptidyl Prolyl Isomerase Pin1-Reference-Cited by-同舟云学术

Human Immunodeficiency Virus Type 1 Replication and Regulation of APOBEC3G by Peptidyl Prolyl Isomerase Pin1

Published:2008-10-15 Issue:20 Volume:82 Page:9928-9936
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Watashi Koichi¹,Khan Mohammad²,Yedavalli Venkat R. K.¹,Yeung Man Lung¹,Strebel Klaus²,Jeang Kuan-Teh¹

Affiliation:

1. Molecular Virology Section

2. Viral Biochemistry Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

Abstract

ABSTRACT APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency virus type 1 (HIV-1) replication. HIV-1 synthesizes a viral infectivity factor (Vif) to counter A3G restriction. Currently, it is poorly understood how A3G expression/activity is regulated by cellular factors. Here, we show that the prolyl isomerase Pin1 protein modulates A3G expression. Pin1 was found to be an A3G-interacting protein that reduces A3G expression and its incorporation into HIV-1 virion, thereby limiting A3G-mediated restriction of HIV-1. Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to moderate A3G activity. These new findings suggest a potential Vif-independent way for HIV-1 to moderate the cellular action of A3G.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01017-08

Reference64 articles.

1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

2. Anderson, J. L., and T. J. Hope. 2008. APOBEC3G restricts early HIV-1 replication in the cytoplasm of target cells. Virology375:1-12.

3. Bennasser, Y., and E. Bahraoui. 2002. HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta. FASEB J.16:546-554.

4. Borgatti, P., G. Zauli, L. C. Cantley, and S. Capitani. 1998. Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. Biochem. Biophys. Res. Commun.242:332-337.

5. Chiu, Y. L., V. B. Soros, J. F. Kreisberg, K. Stopak, W. Yonemoto, and W. C. Greene. 2005. Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature435:108-114.

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. PIN1 is a novel interaction partner and a negative upstream regulator of the transcription factor NFIB;FEBS Letters;2024-09-08

2. Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery;Science Signaling;2024-06-18

3. Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation;Cells;2024-04-23

4. Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities;Biology;2023-07-14

5. Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions;Journal of Medicinal Chemistry;2023-07-13