Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice-Reference-Cited by-同舟云学术

Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice

Published:2021-03-24 Issue:4 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Shiba Sachiko¹,Ikeda Kazuhiro¹,Horie-Inoue Kuniko¹,Azuma Kotaro²,Hasegawa Tomoka³,Amizuka Norio³,Tanaka Tomoaki⁴,Takeiwa Toshihiko¹,Shibata Yasuaki⁵,Koji Takehiko⁵,Inoue Satoshi¹²^ORCID

Affiliation:

1. Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

2. Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

3. Department of Developmental Hard Tissue, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

4. Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

5. Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Abstract

γ-Glutamyl carboxylase (GGCX) is a vitamin K (VK)-dependent enzyme that catalyzes the γ-carboxylation of glutamic acid residues in VK-dependent proteins. The anticoagulant warfarin is known to reduce GGCX activity by inhibiting the VK cycle and was recently shown to disrupt spermatogenesis.

Funder

MEXT | Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Takeda Science Foundation

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00404-20

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1. Vitamin K: Novel molecular mechanisms of action and its roles in osteoporosis