Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes-Reference-Cited by-同舟云学术

Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes

Published:2019-03 Issue:5 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Minocha Shilpi¹,Villeneuve Dominic¹,Praz Viviane¹²,Moret Catherine¹,Lopes Maykel¹,Pinatel Danièle¹,Rib Leonor¹²,Guex Nicolas²,Herr Winship¹

Affiliation:

1. Center for Integrative Genomics, Génopode, University of Lausanne, Lausanne, Switzerland

2. Swiss Institute of Bioinformatics, Génopode, University of Lausanne, Lausanne, Switzerland

Abstract

Host cell factor 1 (HCF-1), encoded by the ubiquitously expressed X-linked gene Hcfc1 , is an epigenetic coregulator important for mouse development and cell proliferation, including during liver regeneration. We used a hepatocyte-specific inducible Hcfc1 knockout allele (called Hcfc1 hepKO ) to induce HCF-1 loss in hepatocytes of hemizygous Hcfc1 hepKO/Y males by 4 days.

Funder

Swiss National Science Foundation

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00405-18

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