Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP C and Other Host-Specific Factors-Reference-Cited by-同舟云学术

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Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP C and Other Host-Specific Factors

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Espinosa Juan Carlos¹^ORCID,Andreoletti Olivier²,Marín-Moreno Alba¹,Lugan Severine²,Aguilar-Calvo Patricia¹,Cassard Hervé²,Lorenzo Patricia¹,Douet Jean-Yves²,Villa-Díaz Ana¹,Aron Naima²,Prieto Irene¹,Huor Alvina²,Torres Juan María¹^ORCID

Affiliation:

1. Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

2. INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France

Abstract

Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.

Funder

EU Projects

Ministerio de Economía y Competitividad

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03508-20

Reference50 articles.

1. Nature of the Scrapie Agent: Self-replication and Scrapie

2. Novel Proteinaceous Infectious Particles Cause Scrapie

3. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

4. Separation and properties of cellular and scrapie prion proteins.

5. Nobel Lecture: Prions

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