Prime-Pull Immunization with a Bivalent M-Protein and Spy-CEP Peptide Vaccine Adjuvanted with CAF®01 Liposomes Induces Both Mucosal and Peripheral Protection from covR/S Mutant Streptococcus pyogenes

Author:

Ozberk Victoria1,Reynolds Simone1,Huo Yongbao1,Calcutt Ainslie1,Eskandari Sharareh1,Dooley Jessica1,Mills Jamie-Lee1,Rasmussen Ida S.2,Dietrich Jes2,Pandey Manisha1,Good Michael F.1

Affiliation:

1. Institute for Glycomics, Griffith University, Gold Coast, Australia

2. Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark

Abstract

A vaccine to control S. pyogenes infection is desperately warranted. S. pyogenes colonizes the upper respiratory tract (URT) and skin, from where it can progress to invasive and immune-mediated diseases.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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