Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone

Author:

Alvarez-Fraga Laura123ORCID,Phan Minh-Duy12ORCID,Goh Kelvin G. K.4ORCID,Nhu Nguyen Thi Khanh12ORCID,Hancock Steven J.12,Allsopp Luke P.5,Peters Kate M.12,Forde Brian M.6ORCID,Roberts Leah W.7,Sullivan Matthew J.4,Totsika Makrina8ORCID,Beatson Scott A.12ORCID,Ulett Glen C.4ORCID,Schembri Mark A.12ORCID

Affiliation:

1. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

2. Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia

3. University Hospital Complex of A Coruña (CHUAC), Biomedical Research Institute of A Coruña (INIBIC), A Coruña, Spain

4. School of Pharmacy and Medical Sciences, and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia

5. National Heart and Lung Institute, Imperial College London, London, UK

6. University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia

7. EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK

8. Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Herston, Queensland, Australia

Abstract

E. coli ST131 is the most common antibiotic resistant UPEC clone associated with human urinary tract and bloodstream infections. Understanding the features of ST131 that have driven its global dissemination remains a critical priority if we are to counter its increasing antibiotic resistance.

Funder

Department of Health | National Health and Medical Research Council

Galician Ministry of Culture, Education, and University Planning and Galician Ministry of Economy, Employment and Industry

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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