Class A Penicillin-Binding Protein-Mediated Cell Wall Synthesis Promotes Structural Integrity during Peptidoglycan Endopeptidase Insufficiency in Vibrio cholerae-Reference-Cited by-同舟云学术

Class A Penicillin-Binding Protein-Mediated Cell Wall Synthesis Promotes Structural Integrity during Peptidoglycan Endopeptidase Insufficiency in Vibrio cholerae

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Murphy Shannon G.¹²^ORCID,Murtha Andrew N.¹²,Zhao Ziyi¹,Alvarez Laura³,Diebold Peter²,Shin Jung-Ho¹,VanNieuwenhze Michael S.⁴,Cava Felipe³^ORCID,Dörr Tobias¹²⁵^ORCID

Affiliation:

1. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA

2. Department of Microbiology, Cornell University, Ithaca, New York, USA

3. The Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden

4. Department of Molecular and Cellular Biochemistry and Department of Biology, Indiana University, Bloomington, Indiana, USA

5. Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, New York, USA

Abstract

Synthesis and turnover of the bacterial cell wall must be tightly coordinated to avoid structural integrity failure and cell death. Details of this coordination are poorly understood, particularly if and how cell wall turnover enzymes are required for the activity of the different cell wall synthesis machines, the aPBPs and the Rod system.

Funder

Knut och Alice Wallenbergs Stiftelse

Molecular Infection Medicine Sweden

Kempestiftelserna

HHS | National Institutes of Health

Swedish Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03596-20