Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41-Reference-Cited by-同舟云学术

Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Maslennikova Alexandra¹,Kruglova Natalia²,Kalinichenko Svetlana¹,Komkov Dmitriy²,Shepelev Mikhail²,Golubev Dmitriy²,Siniavin Andrei³,Vzorov Andrei³⁴,Filatov Alexander⁴⁵,Mazurov Dmitriy²

Affiliation:

1. Cell and Gene Technology Group, Institute of Gene Biology RAS, Moscow, Russia

2. Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology RAS, Moscow, Russia

3. Gamaleya Center for Epidemiology and Microbiology, Moscow, Russia

4. Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

5. Laboratory of Immunochemistry, National Research Center Institute of Immunology of Federal Medical Biological Agency of Russia, Moscow, Russia

Abstract

HIV is a human lentivirus that infects CD4-positive immune cells and, when left untreated, manifests in the fatal disease known as AIDS. Antiretroviral therapy (ART) does not leading to viral clearance, and HIV persists in the organism as a latent provirus.

Funder

Ministry of Science and Higher Education of the Russian Federation

Russian Foundation for Basic Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03589-21

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1. How a Single Patient Influenced HIV Research — 15-Year Follow-up

2. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation