Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway-Reference-Cited by-同舟云学术

Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Jiang Xuefeng¹,Tang Tian¹,Guo Jinfeng¹,Wang Yuhang¹,Li Peipei²,Chen Xiangjun²,Wang Lily²,Wen Yiqun²,Jia Junli¹,Emanuela Garbarino¹,Hu Benshun¹,Chen Shuhua³,Yao Kun¹,Li Linyun⁴,Tang Huaming¹⁵⁶^ORCID

Affiliation:

1. Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China

2. Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China

3. Department of Critical Care Medicine, Changzhou Cancer Hospital Affiliated to Soochow University, Changzhou, People’s Republic of China

4. Department of Medical Genetics, Nanjing Medical University, Nanjing, People’s Republic of China

5. Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, People’s Republic of China

6. The Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, People’s Republic of China

Abstract

HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenous MAVS could facilitate HHV-6B replication. The findings in this study could provide new insights into host-virus interactions and help develop a new therapy against HHV-6B infection.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03505-20

Reference60 articles.

1. Determination and analysis of the complete nucleotide sequence of human herpesvirus

2. The DNA Sequence of Human Herpesvirus-6: Structure, Coding Content, and Genome Evolution

3. Recent topics related to human herpesvirus 6 cell tropism

4. Primary infection by HHV-6 variant B associated with a fatal case of hemophagocytic syndrome;Portolani M;New Microbiol,1997

5. Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative Disorders

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