Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator

Author:

Nagaraja Shruti1,Cai Maggi W.23,Sun Jingjing4,Varet Hugo56ORCID,Sarid Lotem1,Trebicz-Geffen Meirav1,Shaulov Yana1,Mazumdar Mohit7,Legendre Rachel56,Coppée Jean-Yves56,Begley Thomas J.8,Dedon Peter C.34,Gourinath Samudrala7,Guillen Nancy910,Saito-Nakano Yumiko11,Shimokawa Chikako11,Hisaeda Hajime11,Ankri Serge1ORCID

Affiliation:

1. Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

2. Department of Microbiology and Immunology, National University of Singapore, Singapore

3. Singapore-MIT Alliance for Research and Technology, Singapore

4. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

5. Plate-forme Technologique Biomics, Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, Paris, France

6. Hub de Bioinformatique et Biostatistique, Département Biologie Computationnelle, USR 3756 CNRS, Institut Pasteur, Paris, France

7. Jawaharlal Nehru University School of Life Sciences, New Delhi, India

8. Department of Biological Sciences, The RNA Institute at the University at Albany, State University of New York at Albany, Albany, New York, USA

9. Centre National de la Recherche Scientifique, CNRS-ERL9195, Paris, France

10. Institut Pasteur, Paris, France

11. Department of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan

Abstract

Entamoeba histolytica is a unicellular parasite that causes amebiasis. The parasite resides in the colon and feeds on the colonic microbiota.

Funder

Israel Ministry of Health, INFECT-ERA

Israel Science Foundation

Rappaport Institute

US-ISRAEL binational Foundation BSF

Niedersachsen

National Research Foundation Singapore

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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