The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Quinonez Camila G.¹²^ORCID,Lee Jae Jin¹,Lim Juhyeon¹,Odell Mark²³,Lawson Christopher P.⁴,Anyogu Amararachukwu²⁵,Raheem Saki²^ORCID,Eoh Hyungjin¹^ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

2. Department of Life Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

3. School of Life Sciences, University of Lincoln, Lincoln, United Kingdom

4. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

5. School of Biomedical Sciences, University of West London, London, United Kingdom

Abstract

Understanding the mechanisms underlying M. tuberculosis adaptive strategies to achieve drug tolerance is crucial for the identification of new targets and the development of new drugs. Here, we show that acetate medium triggers a drug-tolerant state in M. tuberculosis when challenged with antituberculosis (anti-TB) drugs.

Funder

Quintin Hogg Foundation

American Lung Association

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03559-21

Reference50 articles.

1. WHO. 2021. Global tuberculosis report 2021. https://www.who.int/publications/i/item/9789240037021.

2. The Genetic Requirements for Fast and Slow Growth in Mycobacteria