Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection-Reference-Cited by-同舟云学术

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

De Oliveira David M. P.¹,Forde Brian M.²^ORCID,Phan Minh-Duy¹^ORCID,Steiner Bernhard¹,Zhang Bing³,Zuegg Johannes³,El-deeb Ibrahim M.⁴,Li Gen¹,Keller Nadia¹,Brouwer Stephan¹,Harbison-Price Nichaela¹,Cork Amanda J.¹,Bauer Michelle J.²,Alquethamy Saleh F.⁵,Beatson Scott A.¹^ORCID,Roberts Jason A.²⁶⁷^ORCID,Paterson David L.²,McEwan Alastair G.¹,Blaskovich Mark A. T.³,Schembri Mark A.¹^ORCID,McDevitt Christopher A.⁵^ORCID,von Itzstein Mark⁴^ORCID,Walker Mark J.¹

Affiliation:

1. The University of Queensland, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia

2. The University of Queensland, UQ Centre for Clinical Research, Australian Infectious Diseases Research Centre, Brisbane, QLD, Australia

3. The University of Queensland, Centre for Superbug Solutions, Institute for Molecular Bioscience, Brisbane, QLD, Australia

4. Griffith University, Institute for Glycomics, Gold Coast, QLD, Australia

5. The University of Melbourne, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia

6. Royal Brisbane and Women’s Hospital, Departments of Pharmacy and Intensive Care Medicine, Brisbane, QLD, Australia

7. University of Montpellier, Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, Nîmes, France

Abstract

Within intensive care unit settings, multidrug-resistant (MDR) Acinetobacter baumannii is a major cause of ventilator-associated pneumonia, and hospital-associated outbreaks are becoming increasingly widespread. Antibiotic treatment of A. baumannii infection is often compromised by MDR strains resistant to last-resort β-lactam (e.g., carbapenems), polymyxin, and tetracycline class antibiotics.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03517-21

Reference61 articles.

1. Antimicrobial Resistance in ESKAPE Pathogens

2. Ventilator-Associated Pneumonia due to Drug-Resistant Acinetobacter baumannii: Risk Factors and Mortality Relation with Resistance Profiles, and Independent Predictors of In-Hospital Mortality

3. Acinetobacter baumannii ventilator-associated pneumonia: epidemiology, clinical characteristics, and prognosis factors