Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth

Author:

Halder Luke D.1,Babych Svitlana1,Palme Diana I.1,Mansouri-Ghahnavieh Elham1,Ivanov Lia1,Ashonibare Victory1,Langenhorst Daniela2,Prusty Bhupesh2,Rambach Günter3,Wich Melissa4,Trinks Nora5,Blango Matthew G.6ORCID,Kornitzer Daniel7,Terpitz Ulrich5,Speth Cornelia3,Jungnickel Berit4,Beyersdorf Niklas2,Zipfel Peter F.18,Brakhage Axel A.89ORCID,Skerka Christine1ORCID

Affiliation:

1. Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

2. Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany

3. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

4. Department of Cell Biology, Institute of Biochemistry and Biophysics, Friedrich Schiller University, Jena, Germany

5. Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany

6. Junior Research Group RNA Biology of Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

7. Department of Molecular Microbiology, B. Rappaport Faculty of Medicine, Technion, Haifa, Israel

8. Friedrich Schiller University, Jena, Germany

9. Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

Abstract

Over the last decade, communication between immune cells by extracellular vesicle-associated miRNAs has emerged as an important regulator of the coordinated immune response. Therefore, a thorough understanding of the conversation occurring via miRNAs, especially during infection, may provide novel insights into both the host reaction to the microbe as well as the microbial response.

Funder

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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