Intraocular penetration of rifampin in humans

Author:

Outman W R1,Levitz R E1,Hill D A1,Nightingale C H1

Affiliation:

1. Department of Pharmacy Services, Hartford Hospital, Connecticut 06115.

Abstract

The penetration of rifampin into human aqueous humor was determined in 15 patients undergoing elective cataract surgery. Between 0.9 and 5.5 h after administration of a single 600-mg oral dose, concentrations ranged from 6.0 to 21.5 mg/liter in serum and from less than 0.2 to 1.3 mg/liter in aqueous humor.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference5 articles.

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4. The clinical spectrum of endophthalmitis: incidence, predisposing factors, and features influencing outcome;Shrader S. K.;J. Infect. Dis.,1990

5. Rifampin: spectrum of antibacterial activity;Thornsberry C.;Rev. Infect. Dis.,1983

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