Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance-Reference-Cited by-同舟云学术

Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance

Published:2018-08 Issue:15 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Duernberger Yvonne¹^ORCID,Liu Shu¹,Riemschoss Katrin¹,Paulsen Lydia¹,Bester Romina²,Kuhn Peer-Hendrik³⁴⁵,Schölling Manuel¹,Lichtenthaler Stefan F.³⁵⁶⁷,Vorberg Ina¹⁸^ORCID

Affiliation:

1. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

2. Institute of Virology, Technical University of Munich, Munich, Germany

3. German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

4. Institute of Pathology, Technical University of Munich, Munich, Germany

5. Institute for Advanced Study, Technical University of Munich, Garching, Germany

6. Department of Neuroproteomics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

7. Munich Cluster for Systems Neurology (SyNergy), Technical University of Munich, Munich, Germany

8. Department of Neurology, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany

Abstract

Prions of lower eukaryotes are transmissible protein particles that propagate by converting homotypic soluble proteins into growing protein assemblies. Prion activity is conferred by so-called prion domains, regions of low complexity that are often enriched in glutamines and asparagines (Q/N).

Funder

CoEN

Helmholtz Association

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00111-18

Reference86 articles.

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2. Species barriers in prion diseases–brief review;Moore RA;Arch Virol Suppl,2005