TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity-Reference-Cited by-同舟云学术

TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity

Published:2019-11 Issue:21 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Pike Alexandra M.¹²^ORCID,Strong Margaret A.¹^ORCID,Ouyang John Paul T.¹³^ORCID,Greider Carol W.¹²³^ORCID

Affiliation:

1. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Graduate Program in Biochemistry Cell and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

TIN2 is an important regulator of telomere length, and mutations in TINF2 , the gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we tested the effects of human TIN2 on telomerase activity. We identified a new isoform in human cells, TIN2M, that is expressed at levels similar to those of previously studied TIN2 isoforms.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00593-18

Reference70 articles.

1. The telomere syndromes

2. Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

3. The short and long telomere syndromes: paired paradigms for molecular medicine