Adherence to and Penetration of Human Intestinal Caco-2 Epithelial Cell Monolayers by Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Adherence to and Penetration of Human Intestinal Caco-2 Epithelial Cell Monolayers by Pseudomonas aeruginosa

Published:1998-04 Issue:4 Volume:66 Page:1748-1751
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hirakata Yoichi¹,Izumikawa Kohichi¹,Yamaguchi Toshiyuki¹,Igimi Shizunobu²,Furuya Nobuhiko³,Maesaki Shigefumi⁴,Tomono Kazunori⁴,Yamada Yasuaki¹,Kohno Shigeru⁴,Yamaguchi Keizo³,Kamihira Shimeru¹

Affiliation:

1. Department of Laboratory Medicine1 and

2. Department of Biomedical Food Research, National Institute of Infectious Diseases, Tokyo 162,2 and

3. Department of Microbiology, Toho University School of Medicine, Tokyo 143,3Japan

4. Second Department of Internal Medicine,4 Nagasaki University School of Medicine, Nagasaki 852,

Abstract

ABSTRACT Clinical isolates of Pseudomonas aeruginosa from blood adhered to and penetrated intestinal Caco-2 cell monolayers to a greater degree than did isolates from sputum, with a concomitant drastic decrease in transepithelial electrical resistance. PAO-PR1, an avirulent exotoxin A mutant of PAO1, did not cause a decrease in the resistance. The Caco-2 monolayer system may be useful for the evaluation of certain P. aeruginosa virulence factor activities.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.4.1748-1751.1998

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