Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension-Reference-Cited by-同舟云学术

Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension

Published:2004-11-15 Issue:22 Volume:24 Page:9736-9743
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Morita Hiroki¹,Mazerbourg Sabine¹,Bouley Donna M.²,Luo Ching-Wei¹,Kawamura Kazuhiro¹,Kuwabara Yoshimitsu¹,Baribault Helene³,Tian Hui³,Hsueh Aaron J. W.¹

Affiliation:

1. Division of Reproductive Biology, Department of Obstetrics and Gynecology

2. Department of Comparative Medicine, Stanford University School of Medicine, Stanford

3. Tularik, Inc., South San Francisco, California

Abstract

ABSTRACT The physiological role of an orphan G protein-coupled receptor, LGR5, was investigated by targeted deletion of this seven-transmembrane protein containing a large N-terminal extracellular domain with leucine-rich repeats. LGR5 null mice exhibited 100% neonatal lethality characterized by gastrointestinal tract dilation with air and an absence of milk in the stomach. Gross and histological examination revealed fusion of the tongue to the floor of oral cavity in the mutant newborns and immunostaining of LGR5 expression in the epithelium of the tongue and in the mandible of the wild-type embryos. The observed ankyloglossia phenotype provides a model for understanding the genetic basis of this craniofacial defect in humans and an opportunity to elucidate the physiological role of the LGR5 signaling system during embryonic development.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.24.22.9736-9743.2004

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