Correlation of Resistance to Proflavine and Penicillin in Escherichia coli-Reference-Cited by-同舟云学术

Correlation of Resistance to Proflavine and Penicillin in Escherichia coli

Published:1976-10 Issue:4 Volume:10 Page:765-767
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

McKellar Robin C.¹,McKenzie Colin N.¹,Kushner Donn J.¹

Affiliation:

1. Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5

Abstract

A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also resistant to the other drug. None of the resistant mutants tested possessed β-lactamase activity. These results suggest that resistance to PF and penicillin in E. coli B may be due to permeability changes in the cell envelope.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.10.4.765

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