Clinical and Bacteriological Evaluation of Netilmicin in Gram-Negative Infections-Reference-Cited by-同舟云学术

Clinical and Bacteriological Evaluation of Netilmicin in Gram-Negative Infections

Published:1977-10 Issue:4 Volume:12 Page:503-509
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Klastersky J.¹,Meunier-Carpentier F.¹,Coppens-Kahan L.¹,Daneau D.¹,Prevost J. M.¹

Affiliation:

1. Service de Médecine et Laboratoire d'Investigation Clinique H. J. Tagnon (Section des Maladies Infectieuses), Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium

Abstract

A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gentamicin and other newer aminoglycoside antibiotics. Cross-resistance to netilmicin was found in 9 of 44 gentamicin-resistant strains. A favorable clinical response was observed in 70% of the patients treated with a dose of netilmicin ranging from 4.5 to 7.5 mg/kg. However, the appearance of granular casts was seen in 7 of 10 patients receiving the higher dosage of netilmicin (7.5 mg/kg) and a rise in blood urea nitrogen or serum creatinine levels was observed in 5 of these patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.12.4.503

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