Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013-Reference-Cited by-同舟云学术

Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013

Published:2014-12 Issue:23 Volume:88 Page:13897-13909
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rith Sareth¹,Davis C. Todd²,Duong Veasna¹,Sar Borann²³,Horm Srey Viseth¹,Chin Savuth⁴,Ly Sovann⁵,Laurent Denis⁶,Richner Beat⁶,Oboho Ikwo²⁷,Jang Yunho²,Davis William²,Thor Sharmi²,Balish Amanda²,Iuliano A. Danielle²,Sorn San⁸,Holl Davun⁸,Sok Touch⁵,Seng Heng⁵,Tarantola Arnaud¹,Tsuyuoka Reiko⁹,Parry Amy⁹,Chea Nora⁹,Allal Lotfi¹⁰,Kitsutani Paul²³,Warren Dora²³,Prouty Michael¹¹,Horwood Paul¹,Widdowson Marc-Alain²,Lindstrom Stephen²,Villanueva Julie²,Donis Ruben²,Cox Nancy²,Buchy Philippe¹

Affiliation:

1. Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia

2. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. Centers for Disease Control and Prevention, Phnom Penh, Cambodia

4. National Institute of Public Health, Phnom Penh, Cambodia

5. Communicable Disease Department, Ministry of Health, Phnom Penh, Cambodia

6. Kantha Bopha Hospital, Phnom Penh, Cambodia

7. Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

8. National Veterinary Research Institute, Ministry of Agriculture, Forestry and Fisheries, Phnom Penh, Cambodia

9. World Health Organization, Phnom Penh, Cambodia

10. Food and Agriculture Organization, Phnom Penh, Cambodia

11. U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia

Abstract

ABSTRACT Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01887-14

Reference24 articles.

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4. Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus

5. In Vitro Assessment of Attachment Pattern and Replication Efficiency of H5N1 Influenza A Viruses with Altered Receptor Specificity

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