Affiliation:
1. Department of Medical Microbiology and Immunology, University of Wisconsin—Madison, Madison, Wisconsin, USA
Abstract
Listeria monocytogenes
is a facultative intracellular pathogen that has been used for decades to understand mechanisms of bacterial pathogenesis and both innate and adaptive immunity.
L. monocytogenes
is a potent activator of CD8
+
T-cell-mediated immunity, yet how the innate immune response to infection modulates CD8
+
T-cell responses is incompletely understood. Here, we address how two innate immune pathways triggered by
L. monocytogenes
, type I interferon (IFN) production and inflammasome activation, impact the CD8
+
T-cell response.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
National Science Foundation
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology