Type I Interferon Signaling on Antigen-Presenting Cells Blunts Cell-Mediated Immunity toward Listeria monocytogenes

Abstract

Listeria monocytogenes is a facultative intracellular pathogen that has been used for decades to understand mechanisms of bacterial pathogenesis and both innate and adaptive immunity. L. monocytogenes is a potent activator of CD8 + T-cell-mediated immunity, yet how the innate immune response to infection modulates CD8 + T-cell responses is incompletely understood. Here, we address how two innate immune pathways triggered by L. monocytogenes , type I interferon (IFN) production and inflammasome activation, impact the CD8 + T-cell response.