Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis-Reference-Cited by-同舟云学术

Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis

Published:2021-03-17 Issue:4 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Markham Nicholas O.¹²^ORCID,Bloch Sarah C.³,Shupe John A.³,Laubacher Erin N.¹²,Thomas Audrey K.³,Kroh Heather K.³,Childress Kevin O.³,Peritore-Galve F. Christopher³,Washington M. Kay³,Coffey Robert J.¹²,Lacy D. Borden²³⁴^ORCID

Affiliation:

1. Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

3. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Department of Veterans Affairs Medical Center, Nashville, Tennessee, USA

Abstract

Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly kill cells and induce an inflammatory response in the colonic mucosa.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00543-20

Reference55 articles.