Role of metAB in Methionine Metabolism and Optimal Chicken Colonization in Campylobacter jejuni-Reference-Cited by-同舟云学术

Role of metAB in Methionine Metabolism and Optimal Chicken Colonization in Campylobacter jejuni

Published:2020-12-15 Issue:1 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ruddell Brandon¹,Hassall Alan¹²,Sahin Orhan²,Zhang Qijing¹,Plummer Paul J.¹²,Kreuder Amanda J.¹²^ORCID

Affiliation:

1. Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA

2. Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA

Abstract

Campylobacter jejuni is a zoonotic pathogen and is one of the leading causes of human gastroenteritis worldwide. C. jejuni IA3902 (representative of the sheep abortion clone) is genetically similar to C. jejuni W7 (representative of strain type NCTC 11168); however, there are significant differences in the ability of luxS mutants of these strains to colonize chickens. LuxS is essential for the activated methyl cycle and generates homocysteine for conversion to l -methionine.

Funder

Iowa State University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00542-20

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