Foxp3 + T Regulatory Cells as a Potential Target for Immunotherapy against Primary Infection with Echinococcus multilocularis Eggs

Author:

Wang Junhua12,Cardoso Rita1,Marreros Nelson1,Müller Norbert1,Lundström-Stadelmann Britta1,Siffert Myriam3,Vuitton Dominique A.4,Boué Franck5,Lin Renyong2,Wen Hao2,Gottstein Bruno1ORCID

Affiliation:

1. Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

2. State Key Lab Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

3. Central Animal Facilities, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

4. WHO-Collaborating Centre on Prevention and Treatment of Human Echinococcosis and French National Reference Centre on Alveolar Echinococcosis, University of Franche-Comté and University Hospital, Besançon, France

5. ANSES, Laboratoire de la rage et de la faune sauvage de Nancy, Malzéville, France

Abstract

Alveolar echinococcosis (AE) is a lethal disease caused by infection with the metacestode stage of the helminth Echinococcus multilocularis , which develops into a tumorlike mass in susceptible intermediate hosts. The growth potential of this parasite stage is directly linked to the nature of the surrounding periparasitic immune-mediated processes.

Funder

Swiss National Science Foundation

NDFC

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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