Detection of Newly Secreted Antibodies Predicts Nonrecurrence in Primary Clostridioides difficile Infection-Reference-Cited by-同舟云学术

Detection of Newly Secreted Antibodies Predicts Nonrecurrence in Primary Clostridioides difficile Infection

Published:2022-03-16 Issue:3 Volume:60 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Haddad Natalie S.¹^ORCID,Nozick Sophia¹,Kim Geena¹,Ohanian Shant¹,Kraft Colleen S.²³^ORCID,Rebolledo Paulina A.⁴³^ORCID,Wang Yun²⁵,Wu Hao⁶,Bressler Adam⁷,Le Sang Nguyet Thi⁸,Kuruvilla Merin⁸,Runnstrom Martin C.⁸,Ramonell Richard P.⁸,Cannon L. Edward¹,Lee F. Eun-Hyung¹⁸,Daiss John L.¹^ORCID

Affiliation:

1. MicroB-plex, Inc., Atlanta, GA, USA

2. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA

3. Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA

4. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

5. Department of Pathology and Laboratory Medicine, Grady Memorial Hospital, Atlanta, GA, USA

6. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA

7. Infectious Disease Specialists of Atlanta, Decatur, GA, USA

8. Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University, Atlanta, GA, USA

Abstract

Within 8 weeks of primary Clostridioides difficile infection (CDI), as many as 30% of patients develop the recurrent disease with the associated risks of multiple relapses, morbidity, and economic burden. There are no clear clinical correlates or validated biomarkers that can predict recurrence during primary infection.

Funder

Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.02201-21

Reference50 articles.

1. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

2. Clostridium difficile infection

3. Characterization and risk factors for recurrence of Clostridioides (Clostridium) difficile infection in Japan: A nationwide real-world analysis using a large hospital-based administrative dataset