COVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in Saliva

Author:

Pisanic Nora1,Randad Pranay R.1,Kruczynski Kate1,Manabe Yukari C.23,Thomas David L.2,Pekosz Andrew14ORCID,Klein Sabra L.456,Betenbaugh Michael J.7,Clarke William A.3,Laeyendecker Oliver289,Caturegli Patrizio P.310,Larman H. Benjamin310,Detrick Barbara310,Fairley Jessica K.11,Sherman Amy C.12,Rouphael Nadine12,Edupuganti Srilatha12,Granger Douglas A.13,Granger Steve W.14,Collins Matthew H.12,Heaney Christopher D.168ORCID

Affiliation:

1. Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

2. Division of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

3. Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

4. Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

5. Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

6. Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

7. Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

8. Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

9. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA

10. Division of Immunology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

11. Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

12. The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, Georgia, USA

13. Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, California, USA

14. Salimetrics, LLC, Carlsbad, California, USA

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic that has infected over 36 million and killed over 1 million people. Informed implementation of government public health policies depends on accurate data on SARS-CoV-2 immunity at a population scale. We hypothesized that detection of SARS-CoV-2 salivary antibodies could serve as a noninvasive alternative to serological testing for monitoring of SARS-CoV-2 infection and seropositivity at a population scale.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Environmental Health Sciences

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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