Addition of neuA , the Gene Encoding N -Acylneuraminate Cytidylyl Transferase, Increases the Discriminatory Ability of the Consensus Sequence-Based Scheme for Typing Legionella pneumophila Serogroup 1 Strains-Reference-Cited by-同舟云学术

Addition of neuA , the Gene Encoding N -Acylneuraminate Cytidylyl Transferase, Increases the Discriminatory Ability of the Consensus Sequence-Based Scheme for Typing Legionella pneumophila Serogroup 1 Strains

Published:2007-06 Issue:6 Volume:45 Page:1965-1968
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Ratzow Sandra¹,Gaia Valeria²,Helbig Jürgen Herbert¹,Fry Norman K.³,Lück Paul Christian¹

Affiliation:

1. Institut für Medizinische Mikrobiologie und Hygiene, TU Dresden, Dresden, Germany

2. Instituto Cantonale di Microbiologia, Lugano, Switzerland

3. Health Protection Agency, Centre for Infections, Respiratory and Systemic Infection Laboratory, London, United Kingdom

Abstract

ABSTRACT The standard sequence-based method for the typing of Legionella pneumophila serogroup 1 strains was extended by using the gspA and neuA alleles. The use of neuA as a seventh allele for typing significantly increased the index of discrimination calculated for a panel of unrelated strains (from 0.932 to 0.963) and subdivided some known large common complexes (e.g., 1,4,3,1,1,1). This modification to the standard method is proposed as the method of choice in the epidemiological investigation of L. pneumophila infections.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00261-07

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