Production of BRO β-Lactamases and Resistance to Complement in European Moraxella catarrhalis Isolates

Author:

Schmitz Franz-Josef12,Beeck Andreas1,Perdikouli Mirella1,Boos Mechthild1,Mayer Susanne1,Scheuring Sybille1,Köhrer Karl1,Verhoef Jan2,Fluit Ad C.2

Affiliation:

1. Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany

2. Eijkman-Winkler Institute for Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

ABSTRACT Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were β-lactamase positive. Twenty-two (5.7%) produced BRO-2 β-lactamase. Twenty-one new mutations were found in the putative promoter region of the bro genes. Nineteen percent of all isolates tested were complement sensitive. Resistance to β-lactams is not linked to the phylogenetic lineages associated with susceptibility to complement.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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