Induction of Th1 cytokine responses by mycobacterial antigens in leprosy-Reference-Cited by-同舟云学术

Induction of Th1 cytokine responses by mycobacterial antigens in leprosy

Published:1996-10 Issue:10 Volume:64 Page:4385-4389
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dockrell H M¹,Young S K¹,Britton K¹,Brennan P J¹,Rivoire B¹,Waters M F¹,Lucas S B¹,Shahid F¹,Dojki M¹,Chiang T J¹,Ehsan Q¹,McAdam K P¹,Hussain R¹

Affiliation:

1. Molecular Immunology Unit, Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, United Kingdom. h.dockrell@lshtm.ac.uk

Abstract

Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.64.10.4385-4389.1996

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