Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

Author:

Dai Meiling1,Du Wenjuan1,Martínez-Romero Carles23,Leenders Tim4,Wennekes Tom4,Rimmelzwaan Guus F.5,van Kuppeveld Frank J. M.1,Fouchier Ron A. M.6,Garcia-Sastre Adolfo2378ORCID,de Vries Erik1,de Haan Cornelis A. M.1ORCID

Affiliation:

1. Virology Section, Division of Infectious Diseases & Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

2. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

4. Department Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands

5. Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany

6. Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands

7. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

8. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

Since its emergence in 2009, the pandemic H1N1 influenza A virus (IAV) has caused significant disease and mortality in humans. IAVs contain two envelope glycoproteins, the receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA).

Funder

Chinese Scholarship Council

Dutch Ministry of Economic Affairs, Agriculture and Innovation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Netherlands Organization for Scientific Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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