Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection-Reference-Cited by-同舟云学术

Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Parzych Elizabeth M.¹,Gulati Sunita²,Zheng Bo²,Bah Mamadou A.¹,Elliott Sarah T. C.¹,Chu Jacqueline D.¹,Nowak Nancy²,Reed George W.²,Beurskens Frank J.³,Schuurman Janine²,Rice Peter A.²,Weiner David B.¹,Ram Sanjay²

Affiliation:

1. Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

2. Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

3. Genmab, Utrecht, The Netherlands

Abstract

Neisseria gonorrhoeae has become resistant to most antibiotics in clinical use. Currently, there is no safe and effective vaccine against gonorrhea.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00242-21

Reference52 articles.

1. Marrazzo JM, Apicella MA. 2020. Neisseria gonorrhoeae (gonorrhea), p 2608–2627. In Bennett JE, Dolin R, Blaser MJ (ed), Principles and practice of infectious diseases, 9th ed, vol 2. Elsevier, Philadelphia, PA.

2. Ram S, Rice PA. 2018. Gonococcal infections, p 1122–1129. In Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J (ed), Harrison's principles of internal medicine, 20th ed, vol 1. McGraw Hill Education, New York, NY.

3. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women

4. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1

5. Disseminated Gonococcal Infection

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Innovations in monoclonal antibody-based multipurpose prevention technology (MPT) for the prevention of sexually transmitted infections and unintended pregnancy;Frontiers in Reproductive Health;2024-01-09

2. Evaluating vaccine-elicited antibody activities against Neisseria gonorrhoeae : cross-protective responses elicited by the 4CMenB meningococcal vaccine;Infection and Immunity;2023-12-12

3. Hit ‘em Where It Hurts: Gram-Negative Bacterial Lipopolysaccharide as a Vaccine Target;Microbiology and Molecular Biology Reviews;2023-09-26

4. Evaluating vaccine-elicited antibody activities againstNeisseria gonorrhoeae:cross-protective responses elicited by the 4CMenB meningococcal vaccine;2023-08-04

5. Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in Immunotherapy;Antibodies;2023-07-06