In Vivo Antigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection-Reference-Cited by-同舟云学术

In Vivo Antigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Clemmensen Helena Strand¹²^ORCID,Dube Jean-Yves³⁴⁵,McIntosh Fiona⁴⁵,Rosenkrands Ida¹,Jungersen Gregers¹²,Aagaard Claus¹^ORCID,Andersen Peter¹⁶,Behr Marcel A.³⁴⁵⁷^ORCID,Mortensen Rasmus¹^ORCID

Affiliation:

1. Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark

2. Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark

3. Department of Microbiology and Immunology, McGill University, Montréal, Canada

4. Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada

5. McGill International TB Centre, Montréal, Canada

6. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

7. Department of Medicine, McGill University Health Centre, Montréal, Canada

Abstract

Tuberculosis, caused by Mtb, constitutes a global health crisis of massive proportions, and the impact of the current coronavirus disease 2019 (COVID-19) pandemic is expected to cause a rise in tuberculosis-related deaths. Improved vaccines are therefore needed more than ever, but a lack of knowledge on protective immunity hampers their development.

Funder

Lundbeckfonden

Sundhed og Sygdom, Det Frie Forskningsråd

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00226-21

Reference66 articles.