Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins-Reference-Cited by-同舟云学术

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lun Cheng Man¹,Waheed Abdul A.¹,Majadly Ahlam¹,Powell Nicole¹,Freed Eric O.¹

Affiliation:

1. Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA

Abstract

Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response. In this study, we investigate the mechanism of action of the MARCH family of cellular proteins that disrupt the trafficking and virion incorporation of viral glycoproteins across several virus families.

Funder

HHS | NIH | National Cancer Institute

Intramural AIDS Research Fellowship

Intramural Anti-COVID-19 Program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00219-21

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1. Novel host restriction factors implicated in HIV-1 replication