Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate-Reference-Cited by-同舟云学术

Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kajihara Kimberly K.¹^ORCID,Pantua Homer¹^ORCID,Hernandez-Barry Hilda²^ORCID,Hazen Meredith³^ORCID,Deshmukh Kiran²^ORCID,Chiang Nancy³^ORCID,Ohri Rachana⁴^ORCID,Castellanos Erick R.⁵^ORCID,Martin Lynn⁶^ORCID,Matsumoto Marissa L.⁵^ORCID,Payandeh Jian¹³⁵^ORCID,Storek Kelly M.¹^ORCID,Schneider Kellen³^ORCID,Smith Peter A.¹^ORCID,Koehler Michael F. T.⁷^ORCID,Tsai Siao Ping²^ORCID,Vandlen Richard⁴^ORCID,Loyet Kelly M.²^ORCID,Nakamura Gerald³^ORCID,Pillow Thomas⁷^ORCID,Seshasayee Dhaya³^ORCID,Kapadia Sharookh B.¹^ORCID,Hazenbos Wouter L. W.¹^ORCID

Affiliation:

1. Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA

2. Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA

3. Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA

4. Department of Protein Chemistry, Genentech, Inc., South San Francisco, California, USA

5. Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA

6. Department of BioMolecular Resources, Genentech, Inc., South San Francisco, California, USA

7. Department of Medicinal Chemistry; Genentech, Inc., South San Francisco, California, USA

Abstract

Antibiotic treatment of life-threatening P. aeruginosa infections is associated with low clinical success, despite the availability of antibiotics that are active in standard microbiological in vitro assays, affirming the need for new therapeutic approaches. Antibiotics often fail in the preclinical stage due to insufficient efficacy against P. aeruginosa .

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00202-21

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