Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase-Reference-Cited by-同舟云学术

Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rinaldi Jimena¹,Fernández Ignacio¹,Shin Heewhan²,Sycz Gabriela¹,Gunawardana Semini²,Kumarapperuma Indika²,Paz Juan M.¹,Otero Lisandro H.¹³,Cerutti María L.¹³,Zorreguieta Ángeles¹,Ren Zhong²,Klinke Sebastián¹³^ORCID,Yang Xiaojing²⁴^ORCID,Goldbaum Fernando A.¹³^ORCID

Affiliation:

1. Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina

2. Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA

3. Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina

4. Department of Ophthalmology and Vision Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

Abstract

Bacteria employ two-component systems (TCSs) to sense and respond to changes in their surroundings. At the core of the TCS signaling pathway is the multidomain sensor histidine kinase, where the enzymatic activity of its output domain is allosterically controlled by the input signal perceived by the sensor domain.

Funder

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

HHS | National Institutes of Health

Chicago Biomedical Consortium

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00264-21

Reference62 articles.

1. Two-Component Sensing and Regulation: How Do Histidine Kinases Talk with Response Regulators at the Molecular Level?