Evolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in Fungi-Reference-Cited by-同舟云学术

Evolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in Fungi

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mosunova Olga V.¹,Navarro-Muñoz Jorge C.¹,Haksar Diksha¹,van Neer Jacq¹,Hoeksma Jelmer²³,den Hertog Jeroen³⁴^ORCID,Collemare Jérôme¹^ORCID

Affiliation:

1. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

2. Hubrecht Institute-KNAW, Utrecht, The Netherlands

3. University Medical Center Utrecht, Utrecht, The Netherlands

4. Institute Biology Leiden, Leiden University, Leiden, The Netherlands

Abstract

Fungi have provided us with life-changing small bioactive molecules, with the best-known examples being the first broad-spectrum antibiotic penicillin, immunosuppressive cyclosporine, and cholesterol-lowering statins. Since the 1980s, exploration of chemical diversity in nature has been highly reduced.

Funder

Koninklijke Nederlandse Akademie van Wetenschappen

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00223-22

Reference52 articles.

1. Natural products in drug discovery: advances and opportunities

2. Rethinking Antibiotic Research and Development: World War II and the Penicillin Collaborative

3. Fungal natural products in research and development