InvL, an Invasin-Like Adhesin, Is a Type II Secretion System Substrate Required for Acinetobacter baumannii Uropathogenesis

Author:

Jackson-Litteken Clay D.1ORCID,Di Venanzio Gisela1,Le Nguyen-Hung1,Scott Nichollas E.2ORCID,Djahanschiri Bardya3,Distel Jesus S.1,Pardue Evan J.1,Ebersberger Ingo345,Feldman Mario F.1ORCID

Affiliation:

1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

2. Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia

3. Applied Bioinformatics Group, Institute of Cell Biology and Neuroscience, Goethe University, Frankfurt am Main, Germany

4. Senckenberg Biodiversity and Climate Research Centre (S-BIKF), Frankfurt am Main, Germany

5. LOEWE Center for Translational Biodiversity Genomics (TBG), Frankfurt am Main, Germany

Abstract

While pathogenic Acinetobacter can cause various infections, we recently found that 20% of clinical isolates come from urinary sources. Despite the clinical relevance of Acinetobacter as a uropathogen, few virulence factors involved in urinary tract colonization have been defined.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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