Affiliation:
1. John Innes Centre, Norwich, United Kingdom
Abstract
ABSTRACT
The genomes of actinomycetes contain numerous gene clusters potentially able to encode the production of many antibiotics and other specialized metabolites that are not expressed during growth under typical laboratory conditions. Undoubtedly, this reflects the soil habitat of these organisms, which is highly complex physically, chemically, and biotically; the majority of the compounds that make up the specialized metabolome are therefore adaptive only under specific conditions. While there have been numerous previous reports of “waking up” the “sleeping” gene clusters, many involving genetic interventions or nutritional challenges, the role of competing microorganisms has been comparatively little studied. Now, Traxler et al. [M. F. Traxler, J. D. Watrous, T. Alexandrov, P. C. Dorrestein, and R. Kolter, mBio 4(4):e00459-13, 2013, doi:10.1128/mBio.00459-13] have used the recently described technique of microscale imaging mass spectrometry to analyze in detail the stimulation of specialized metabolite production by the model actinomycete
Streptomyces coelicolor
A3(2) by growth in proximity to other actinomycetes. The striking finding from these experiments was that growth of
S. coelicolor
close to each of the five other actinomycetes studied caused it to produce many specialized metabolites that were not made when it was grown in isolation and that the majority of the compounds were interaction specific, i.e., they occurred only in one of the five pairwise combinations, emphasizing the highly specific nature of the interactions. These observations contribute substantially to the increasing awareness of communication between microorganisms in complex natural communities, as well as auguring well for the discovery of useful specialized metabolites based on microbial interactions.
Publisher
American Society for Microbiology
Reference13 articles.
1. HopwoodDA . 2007. Streptomyces in nature and medicine: the antibiotic makers. Oxford University Press, New York, NY.
2. Renaissance in antibacterial discovery from actinomycetes
3. Sequence-Based Analysis of Secondary-Metabolite Biosynthesis in Marine Actinobacteria
4. ChaterKF MerrickMJ . 1979. Streptomycetes, p 93–114. In ParrishJH (ed), Developmental biology of prokaryotes. Blackwell Publishing, Oxford, United Kingdom.
5. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献