Affiliation:
1. Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, Texas, USA
Abstract
ABSTRACT
Chronic polymicrobial infections are associated with increased virulence compared to monospecies infections. However, our understanding of microbial dynamics during polymicrobial infection is limited. A recent study by Limoli and colleagues (D. H. Limoli, G. B. Whitfield, T. Kitao, M. L. Ivey, M. R. Davis, Jr., et al., mBio 8:e00186-17, 2017,
https://doi.org/10.1128/mBio.00186-17
) provides insight into a mechanism that may contribute to the coexistence of
Pseudomonas aeruginosa
and
Staphylococcus aureus
in the cystic fibrosis (CF) lung. CF lung infections have frequently been used to investigate microbial interactions due to both the complex polymicrobial community and chronic nature of these infections. The hypothesis of Limoli et al. is that the conversion of
P. aeruginosa
to its mucoidy phenotype during chronic CF infection promotes coexistence by diminishing its ability to kill
S. aureus
. Highlighting a new facet of microbial interaction between two species that are traditionally thought of as competitors, this study provides a platform for studying community assembly in a relevant infection setting.
Funder
Cystic Fibrosis Foundation
Publisher
American Society for Microbiology
Cited by
6 articles.
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