Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector-Reference-Cited by-同舟云学术

Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector

Published:2021-05-18 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Tomita Tadakimi¹^ORCID,Mukhopadhyay Debanjan²,Han Bing¹,Yakubu Rama¹,Tu Vincent¹,Mayoral Joshua¹,Sugi Tatsuki¹,Ma Yanfen¹,Saeij Jeroen P. J.²^ORCID,Weiss Louis M.¹³^ORCID

Affiliation:

1. Department of Pathology, Albert Einstein College of Medicine, New York, New York, USA

2. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA

3. Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA

Abstract

Toxoplasma gondii is an Apicomplexan that infects a third of humans, causing encephalitis in AIDS patients and intellectual disabilities in congenitally infected patients. We determined that one of the cyst matrix proteins, MAG1, which had been thought to be an innate structural protein, can be secreted into the host cell and suppress the host immune reaction.

Funder

HHS | National Institutes of Health

American Heart Association

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00603-21

Reference47 articles.

1. Weiss LM, Kim K (ed). 2013. Toxoplasma gondii: the model Apicomplexan—perspectives and methods, 2nd ed. Academic Press, London, United Kingdom.

2. Penetration of CD8+ Cytotoxic T Cells into Large Target, Tissue Cysts of Toxoplasma gondii, Leads to Its Elimination