Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing-Reference-Cited by-同舟云学术

Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing

Published:2016-11 Issue:11 Volume:60 Page:6962-6964
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

de Curraize Claire¹²,Kumanski Sylvain²,Micaëlo Maïté²³⁴,Fournet Nelly⁵,La Ruche Guy⁵,Meunier Fabienne²,Amarsy Rishma²³⁴,Jacquier Hervé²³⁴,Cambau Emmanuelle²³⁴,Goubard Agathe⁶,Bercot Béatrice²³⁴^ORCID

Affiliation:

1. Laboratory of Bacteriology, University Hospital of Dijon, Dijon, France

2. APHP, Lariboisière–St Louis-Fernand Widal Hospital, Laboratory of Bacteriology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France

3. University Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France

4. INSERM, IAME, UMR 1137, Paris, France

5. French Institute for Public Heath Surveillance (InVS), Department of Infectious Diseases, Saint-Maurice, France

6. Alfred Fournier Institute, National Reference Centre for Gonococci, Paris, France

Abstract

ABSTRACT Two extended-spectrum cephalosporin-resistant Neisseria gonorrhoeae isolates were discovered among 6,340 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug-resistant N. gonorrhoeae isolate harboring a penA mosaic; whole-genome sequencing highlighted an additional R251H substitution in the ftsX gene recently involved in cephalosporin resistance. The other, ceftriaxone-resistant isolate (MIC, 0.25 mg/liter) harbored the PBP2 pattern XXXVI plus a P551S substitution and belonged to sequence type ST1579 (multilocus sequence typing [MLST]).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01568-16

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