Affiliation:
1. The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, Oregon 97070
Abstract
ABSTRACT
This study assessed the spectrum of activity of torezolid (TR-700), the active moiety of torezolid phosphate (TR-701), and proposes tentative MIC and disk diffusion breakpoints as well as quality control ranges. The
in vitro
susceptibilities of 1,096 bacterial isolates, representing 23 different species or phenotypic groups, were determined for torezolid, linezolid, cefotaxime, and levofloxacin using Clinical and Laboratory Standards Institute (CLSI) broth microdilution MICs, minimum bactericidal concentrations (MBCs), agar dilution, and disk diffusion testing methods. Torezolid was very active against the majority of Gram-positive strains, including methicillin-susceptible and -resistant
Staphylococcus aureus
(MIC
50
= 0.25 μg/ml, MIC
90
≤ 0.5 μg/ml), coagulase-negative staphylococci (CNS; MIC
50
= 0.25 μg/ml, MIC
90
≤ 0.5 μg/ml), enterococci (MIC
50
and MIC
90
≤ 0.5 μg/ml), and streptococci (MIC
50
and MIC
90
≤ 0.25 μg/ml). Based upon MIC
90
s, torezolid was 4-fold more active than linezolid against
S. aureus
, coagulase-negative staphylococci, and the enterococci and 8-fold more active than linezolid against the streptococci. With the use of tentative MIC breakpoints of ≤2 μg/ml for susceptibility, torezolid disk diffusion zone diameter breakpoints are proposed using a 20-μg disk. In addition, MIC quality control ranges of torezolid were determined for three CLSI-recognized standard ATCC reference strains.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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