A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during Staphylococcus aureus Bone and Joint Infections-Reference-Cited by-同舟云学术

A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during Staphylococcus aureus Bone and Joint Infections

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Courjon Johan¹²^ORCID,Garzaro Margaux¹,Roger Pierre-Marie³,Ruimy Raymond²⁴,Lavrut Thibaud⁵⁶,Chelli Mikaël⁷,Raynier Jean-Luc⁷,Chirio David¹⁶^ORCID,Demonchy Elisa¹,Cabane Laura⁸,Jehl François⁹,Trojani Christophe⁶⁷,Grillon Antoine⁹,Goutelle Sylvain¹⁰¹¹¹²^ORCID

Affiliation:

1. Université Côte d’Azur, CHU Nice, Infectiologie, Nice, France

2. Université Côte d’Azur, CHU, INSERM, C3M, Nice, France

3. Infectiologie, CHU de Pointe-à-Pitre, Pointe-à-Pitre, France

4. Laboratoire de Bactériologie, Hôpital Archet 2, CHU Nice, Nice, France

5. Pharmacologie, Hôpital Pasteur, Centre Hospitalier Universitaire de Nice, Nice, France

6. Université Côte d’Azur, Nice, France

7. Service de Chirurgie Orthopédique et Chirurgie du Sport, Institut Universitaire Locomoteur et du Sport, Hôpital Pasteur 2, CHU Nice, Nice, France

8. Rhumatologie, Hôpital Pasteur 2, CHU Nice, Nice, France

9. Fédération de Médecine Translationnelle de Strasbourg, EA7290 Virulence Bactérienne Précoce, CHRU Strasbourg, Institut de Bactériologie, Université de Strasbourg, Strasbourg, France

10. Hospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France

11. Université Lyon, Université Lyon 1, ISPB, Faculté de Pharmacie de Lyon, Lyon, France

12. Université Lyon, Université Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France

Abstract

Intravenous administration of antibiotics is recommended during the early phase of methicillin-susceptible S. aureus (MSSA) bone and joint infection (BJI). We sought to compare the plasma concentrations of cloxacillin administered alternately by continuous and intermittent infusion (CI and ItI) in patients with MSSA BJI. In this prospective crossover trial, patients were randomly assigned to receive either 3 days of CI (two 75-mg/kg 12-h cloxacillin infusions per day) and then 3 days of ItI (four 37.

Funder

Astellas Pharma Europe

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01562-20

Reference17 articles.

1. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

2. Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice Anymore

3. Continuous Infusion Versus Intermittent Bolus of Beta-Lactams in Critically Ill Patients with Respiratory Infections: A Systematic Review and Meta-analysis