Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival-Reference-Cited by-同舟云学术

Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival

Published:2018-12 Issue:23 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Alsanafi Mariam¹,Kelly Samuel L.²³,Jubair Karawan¹,McNaughton Melissa¹,Tate Rothwelle J.¹,Merrill Alfred H.²³,Pyne Susan¹,Pyne Nigel J.¹

Affiliation:

1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom

2. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA

3. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA

Abstract

There is controversy concerning the role of dihydroceramide desaturase (Degs1) in regulating cell survival, with studies showing that it can both promote and protect against apoptosis. We have therefore investigated the molecular basis for these opposing roles of Degs1.

Funder

Kuwait Government

Smithgill Endowed Chair Funds

None

University of Strathclyde

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00222-18

Reference43 articles.