Affiliation:
1. Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
Abstract
Cabrera-Juarez, Emiliano
(Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md.)
and Roger M. Herriott
. Ultraviolet irradiation of native and denatured transforming deoxyribonucleic acid from
Haemophilus influenzae
. J. Bacteriol.
85:
671–675. 1963.—Two antibiotic-resistance markers in denatured deoxyribonucleic acid (DNA) from
Haemophilus influenzae
showed about the same sensitivity to ultraviolet irradiation as in native DNA. The resistance of markers in denatured DNA to ultraviolet (UV) light increases with alkalinity up to pH 12. New transforming markers or genetic “lethals” were not produced by in vitro irradiation of either native or denatured DNA. The UV irradiation of the denatured DNA reduces its capacity to form new markers with nitrous acid. Nitrous acid reactivated some of the intrinsic marker destroyed by UV irradiation of denatured transforming DNA.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference14 articles.
1. Induction of streptomycin resistance in sensitive Hemophilus influenzae by extracts containing deoxyribonucleic acid from resistant Hemophilus influenzae;ALEXANDER H. E.;J. Exptl. Med.,1953
2. Reversible;GEIDUSCHEK P.;DNA. Proc. Natl. Acad. Sci. U.,1961
3. Studies on transformation of Hemophilus influenzae;GOODGAL S. H.;I. Competence. J. Gen. Physiol.,1961
4. The mutagenic action of nitrous acid on "singlestranded;HORN E. E.;(denatured) hemophilus transforming DNA. Proc. Natl. Acad. Sci. U.,1962
5. Studies on transformations of Hemophilus influenzae. III. The genotypes and phenotypic patterns of three streptomycin-resistant mutants;R. M.;J. Gen. Physiol.,1961
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献